Version: 8.0.0
Date: Tue Jan 28 2025
Lin28a
Mus musculusMGI:1890546
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Lin28a

Species
Mus musculus
Symbol
Lin28a
Name
lin-28 homolog A
Synonyms
  • AL024421
  • expressed sequence AL024421
Biotype
protein coding gene
Automated Description
Enables RNA binding activity and translation initiation factor binding activity. Involved in several processes, including RNA metabolic process; cellular response to glucose stimulus; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Located in nucleolus and rough endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; limb primordium; reproductive system; and tooth. Used to study nephroblastoma. Orthologous to human LIN28A (lin-28 homolog A).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased birth weight and postnatal lethality. In another report, mice homozygous for the same or an identical allele exhibit reduced premordial germ cells and fertility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46109
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            133.732M133.734M133.736M133.738M133.740M133.742M133.744M133.746M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Lin28a molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Lin28a role
              Lin28a genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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