Gene

Sh3rf1

Species
Mus musculus
Symbol
Sh3rf1
Name
SH3 domain containing ring finger 1
Synonyms
  • 2200003J05Rik
  • expressed sequence R75531
Biotype
protein coding gene
Automated Description
Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit decreased dendritic spine length and density, impaired spatial learning and reference memory, impaired contextual conditioning, increased digging, impaired nest building, decreased social investigation, reduced vocalization, decreased excitatory postsynaptic current amplitude, and reduced long term potentiation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14167
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
61.68M61.70M61.72M61.74M61.76M61.78M61.80M61.82M61.84M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions