Gene

Serpinb1a

Species
Mus musculus
Symbol
Serpinb1a
Name
serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms
  • 1190005M04Rik
  • AI325983
Biotype
protein coding gene
Automated Description
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including inflammatory response; negative regulation of interleukin-1 beta production; and type B pancreatic cell proliferation. Acts upstream of or within regulation of protein catabolic process. Located in extracellular region. Is expressed in bladder wall; brain; embryo mesenchyme; gut; and liver lobe. Orthologous to human SERPINB1 (serpin family B member 1).
MGI Description
PHENOTYPE: Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11461
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Serpinb1a molecule type
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            Genetic Interactions

            Serpinb1a role
            Serpinb1a genetic perturbation
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