Gene

Dpy30

Species
Mus musculus
Symbol
Dpy30
Name
dpy-30, histone methyltransferase complex regulatory subunit
Synonyms
  • 2810410M20Rik
  • Aip1
Biotype
protein coding gene
Automated Description
Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport and transcription initiation-coupled chromatin remodeling. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in several structures, including alimentary system; cerebral cortex; lung; nose; and submandibular gland primordium. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit).
MGI Description
PHENOTYPE: Embryos homozygous for a knock-out allele die between E7.5 and E9.5 exhibiting abnormal post-implantation development associated with absence of the primitive streak and impaired gastrulation of the pluripotent epiblast. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            74.608M74.610M74.612M74.614M74.616M74.618M74.620M74.622M74.624M74.626M74.628M74.630M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Dpy30 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Dpy30 role
              Dpy30 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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