Gene

Sar1b

Species
Mus musculus
Symbol
Sar1b
Name
secretion associated Ras related GTPase 1B
Synonyms
  • 2310075M17Rik
  • 2900019I22Rik
Biotype
protein coding gene
Automated Description
Predicted to enable G protein activity and amino acid sensor activity. Involved in lipid export from cell and lipoprotein transport. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site and lysosomal membrane. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and cortical preplate. Used to study chylomicron retention disease. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1B (secretion associated Ras related GTPase 1B).
MGI Description
PHENOTYPE: Mice homozygous for a null allele show late-gestational lethality. Heterozygous mice exhibit lower triglyceride, total cholesterol, and HDL cholesterol levels, fat malabsorption, and reduced chylomicron secretion. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45684
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
51.655M51.660M51.665M51.670M51.675M51.680M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions