Gene

Alkbh7

Species
Mus musculus
Symbol
Alkbh7
Name
alkB homolog 7
Synonyms
  • 2310045B01Rik
  • 2510008E23Rik
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Involved in fatty acid metabolic process and regulation of lipid storage. Located in mitochondrial matrix. Is expressed in brown fat. Used to study obesity. Orthologous to human ALKBH7 (alkB homolog 7).
MGI Description
PHENOTYPE: Homozygous knockout affects lipid and carbohydrate metabolism which leads to obesity and increased sensitivity to diet-induced obesity. It also increases resistance to alkylation-induced cell death and mortality in males (and females for some tissues) and protects the heart from ischemia-reperfusion (IR) injury in males. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21052
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
57.3044M57.3046M57.3048M57.3050M57.3052M57.3054M57.3056M57.3058M57.3060M57.3062M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions