Predicted to enable metal ion binding activity. Involved in fatty acid metabolic process and regulation of lipid storage. Located in mitochondrial matrix. Is expressed in brown fat. Used to study obesity. Orthologous to human ALKBH7 (alkB homolog 7).
MGI Description
PHENOTYPE: Homozygous knockout affects lipid and carbohydrate metabolism which leads to obesity and increased sensitivity to diet-induced obesity. It also increases resistance to alkylation-induced cell death and mortality in males (and females for some tissues) and protects the heart from ischemia-reperfusion (IR) injury in males. [provided by MGI curators]