late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms
2400001E08Rik
AABR07038019.1
Biotype
protein coding gene
Automated Description
Enables protein-membrane adaptor activity. Involved in several processes, including lysosome localization; positive regulation of intracellular signal transduction; and regulation of receptor recycling. Is active in lysosomal membrane. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit growth arrest and lethality at E7 and abnormal visceral endoderm with abnormal endosome-like organelles and small lysosomes. [provided by MGI curators]