Gene

Atg4b

Species
Mus musculus
Symbol
Atg4b
Name
autophagy related 4B, cysteine peptidase
Synonyms
  • 2510009N07Rik
  • APG4 (ATG4) autophagy-related homolog B (S. cerevisiae)
Biotype
protein coding gene
Automated Description
Enables cysteine-type peptidase activity. Involved in several processes, including autophagosome assembly; otolith mineralization completed early in development; and protein delipidation. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; gut; lymph node; and sensory organ. Orthologous to human ATG4B (autophagy related 4B cysteine peptidase).
MGI Description
PHENOTYPE: Mice homozygous for a gene trap allele exhibit decreased autophagy, impaired swimming, circling, head tilting, and abnormal utricle, saccular, and otolith morphology. Mice homozygous for another gene trap allele exhibit partial preweaning lethality and impaired motor coordination and learning. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22624
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            93.685M93.690M93.695M93.700M93.705M93.710M93.715M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Atg4b molecule type
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              Genetic Interactions

              Atg4b role
              Atg4b genetic perturbation
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