Enables UFM1 activating enzyme activity. Involved in myeloid cell differentiation; protein ufmylation; and regulation of type II interferon production. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele die at E12.5. [provided by MGI curators]