Version: 8.0.0
Date: Tue Jan 28 2025
Clxn
Mus musculusMGI:1914043
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Clxn

Species
Mus musculus
Symbol
Clxn
Name
calaxin
Synonyms
  • 4930449A16Rik
  • 5430404L10Rik
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including beta-tubulin binding activity; calcium-dependent outer dynein arm binding activity; and dynein heavy chain binding activity. Involved in regulation of flagellated sperm motility. Located in cilium. Is expressed in central nervous system and pancreas trunk epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin).
MGI Description
PHENOTYPE: Homozygotes for a knock-out allele show partial lethality during fetal growth and development, hydrocephaly, situs inversus, enlarged brain ventricles, cardiac hypertrophy, reduced motility and fluid flows in sperm flagella and epithelial cilia, and defects in nodal cilia formation and motility. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23055
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Clxn molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Clxn role
            Clxn genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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