Enables ubiquitin protein ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of lymphocyte proliferation; and regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PELI1 (pellino E3 ubiquitin protein ligase 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced proinflammatory cytokine production, B cell proliferation, and mortality following treatment with LPS or pIpC. [provided by MGI curators]