Gene

Peli1

Species
Mus musculus
Symbol
Peli1
Name
pellino 1
Synonyms
  • 2810468L03Rik
  • A930031K15Rik
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of lymphocyte proliferation; and regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PELI1 (pellino E3 ubiquitin protein ligase 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced proinflammatory cytokine production, B cell proliferation, and mortality following treatment with LPS or pIpC. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12098
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
21.05M21.06M21.07M21.08M21.09M21.10M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions