Gene

Dock7

Species
Mus musculus
Symbol
Dock7
Name
dedicator of cytokinesis 7
Synonyms
  • 3110056M06Rik
  • gene model 430, (NCBI)
Biotype
protein coding gene
Automated Description
Enables small GTPase binding activity. Involved in negative regulation of cold-induced thermogenesis; nervous system development; and regulation of neurogenesis. Acts upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Is active in neuromuscular junction. Is expressed in several structures, including alimentary system; lung; nervous system; placenta; and sensory organ. Used to study platelet storage pool deficiency. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7).
MGI Description
PHENOTYPE: Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23317
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
98.84M98.86M98.88M98.90M98.92M98.94M98.96M98.98M99.00M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions