Version: 8.0.0
Date: Tue Jan 28 2025
C1qtnf4
Mus musculusMGI:1914695
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

C1qtnf4

Species
Mus musculus
Symbol
C1qtnf4
Name
C1q and tumor necrosis factor related protein 4
Synonyms
  • 0710001E10Rik
  • 9430004J15Rik
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via STAT; protein phosphorylation; and reduction of food intake in response to dietary excess. Predicted to be active in extracellular space. Is expressed in brain and retina. Orthologous to human C1QTNF4 (C1q and TNF related 4).
MGI Description
PHENOTYPE: Male mice homozygous for a mutation are viable and show normal fertility. Mice homozygous for a null allele exhibit increased sensitivity to LPS treatment with increased mortality. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22923
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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        Has Phenotype Annotations
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          Models

          Model name
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          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            90.7165M90.7170M90.7175M90.7180M90.7185M90.7190M90.7195M90.7200M90.7205M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            C1qtnf4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              C1qtnf4 role
              C1qtnf4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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