Gene

Rnls

Species
Mus musculus
Symbol
Rnls
Name
renalase, FAD-dependent amine oxidase
Synonyms
  • 6530404N21Rik
  • RGD1309804
Biotype
polymorphic pseudogene
Automated Description
Enables oxidoreductase activity. Acts upstream of or within several processes, including catecholamine metabolic process; phosphate ion homeostasis; and response to norepinephrine. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23357
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
33.15M33.20M33.25M33.30M33.35M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions