Enables protein serine/threonine phosphatase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of cGAS/STING signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal embryonic development and embryonic lethality. Mice homozygous for a conditional allele activated in skin cells exhibit increased susceptibility to chemically induced skin tumors with increased proliferative and inflammatory responses in the skin. [provided by MGI curators]