Gene

Spire1

Species
Mus musculus
Symbol
Spire1
Name
spire type actin nucleation factor 1
Synonyms
  • 6030430B19Rik
  • AI415299
Biotype
protein coding gene
Automated Description
Predicted to enable microtubule binding activity. Involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and intracellular transport. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Colocalizes with cleavage furrow. Is expressed in several structures, including central nervous system; genitourinary system; intestine; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile with normal brain anatomy and intact visual and motor functions in both sexes, but show a male-specific increase in contextual and cued fear memory. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21345
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            67.64M67.66M67.68M67.70M67.72M67.74M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Spire1 molecule type
            Interactor gene
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              Genetic Interactions

              Spire1 role
              Spire1 genetic perturbation
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