Gene

Iftap

Species
Mus musculus
Symbol
Iftap
Name
intraflagellar transport associated protein
Synonyms
  • B230118H07Rik
  • NWC
Biotype
protein coding gene
Automated Description
Enables intraciliary transport particle A binding activity. Acts upstream of or within acrosome reaction and spermatogenesis. Located in 9+0 non-motile cilium and cytosol. Is expressed in cerebral cortex ventricular layer and retina. Orthologous to human IFTAP (intraflagellar transport associated protein).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal and fertile under standard laboratory conditions. Under non-standard mating conditions, males show reduced sperm competitiveness, sperm head abnormalities, and reduced sperm ability to fertilize cumulus-intact eggs in vitro. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR35543
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensIFTAP10 of 10YesYes  
Rattus norvegicusIftap9 of 9YesYes   
Xenopus tropicalisiftap9 of 9YesYes   
Danio rerioiftap9 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal copulation behavior
abnormal sperm head morphology
impaired acrosome reaction
impaired fertilization
reduced male fertility
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Iftap (Mmu)
IFTAP (Hsa)
Iftap (Rno)
iftap (Xtr)
iftap (Dre)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCm39
Viewer Help
101.40M101.41M101.42M101.43M101.44M101.45M101.46M101.47MIftapENSMUST00000090513ENSMUST00000099682ENSMUST00000111231ENSMUST00000128898ENSMUST00000136601ENSMUST00000138903ENSMUST00000160037ENSMUST00000160722ENSMUST00000177152Maximum features displayed. See full view for more.
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Iftaptm1b(KOMP)Wtsi
  • NWC-KO
  • NWC-KOMPcre
allele
Yes
Iftaptm1a(KOMP)Wtsi
  • B230118H07Riktm1a(KOMP)Wtsi
  • NWC-KOMP
allele
Iftaptm1Mnz
  • Nwctmpro1
allele
NC_000068.8:g.101461304T>Cvariant
SNP
  • 3 prime UTR variant
NC_000068.8:g.101461340A>Gvariant
SNP
  • 3 prime UTR variant
NC_000068.8:g.101461964C>Tvariant
SNP
  • 3 prime UTR variant
NC_000068.8:g.101462119C>Gvariant
SNP
  • 3 prime UTR variant
NC_000068.8:g.101457291G>Avariant
SNP
  • intron variant
NC_000068.8:g.101464873T>Cvariant
SNP
  • intron variant
NC_000068.8:g.101465488G>Avariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Iftaptm1b(KOMP)Wtsi/Iftaptm1b(KOMP)Wtsi [background:] involves: C57BL/6J * C57BL/6N
  • abnormal copulation behavior
  • abnormal sperm head morphology
MGI
Iftaptm1Mnz/Iftaptm1Mnz [background:] Not SpecifiedMGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
101.40M101.41M101.42M101.43M101.44M101.45MENSMUST00000090513 (Iftap)ENSMUST00000099682 (Iftap)ENSMUST00000111231 (Iftap)ENSMUST00000128898 (Iftap)ENSMUST00000136601 (Iftap)ENSMUST00000138903 (Iftap)ENSMUST00000160037 (Iftap)ENSMUST00000160722 (Iftap)ENSMUST00000177152 (Iftap)NM_001362687.1 (Iftap)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

Transcript: Mode:

 

>NM_026592.4-cds 2:101,391,124-101,459,376(-)
ATGCTTGCTCAAATACCGAGGCCAGAGATAATGGATGAAGATCAGTTAATGAAAGAAGTCTTGGATAAGTTTGTCAACTGCCATGAGCAAACCTATGAAGAATTTCTGAGCACTTTCACTCATCTTTCAAAAGAGGATAATGTGGCCAAATGGGGAGCACATGGAACTGATTcatcagaaaatatattttctactgTAAAATGGAATCATAAAACTGAATCAAATGGTCGTCATTTTAGAAATACATCCATCTTTCTTCACACTTCATCGGAACACTCAGAAGAGGACCAGATTGTGATTGATGAAGGCCACAAAGTTGGGAGTTCCTTTCAAGGTGATATGACCCGGGCTGGAAAGGTGAAGgTAGACAACTTCCTAGACTTAGAAGATGTGGACATGGAGGAAGAGAGTAAGCCCCAGATGAACAAGGATTGCCTGCTACTTCCAGGTGAGGTGGAACAGGATATAAGCACCAGCGTTCCATCTTATGATCCTTCTGTGGACCTACCGCTCACCTCTGAGGTGAGGCCAAAGCCTGCTGTGGGAAGGACTCAGAAACAAACCGAAGAGATACTTGGAGATGAAGTTCAGCCCTTCTTTCTCGATGAAGAATTTGATTATGACAATGTGACTCTCACTCCTAAGTTTACTGCTGGAGAGATAGCAACCATCCAAGAGCTATCTAAGCAAAAGAGAGTGGGTTCCGGTACAAACGTGTGCGAACTCCATGACTGA

 Legend:

  • Up/downstream
  • UTR
  • Coding
  • Intron
  • Genomic (i.e., unprocessed)
  • Amino acid

 IMPORTANT NOTE: Transcript and protein sequences here are derived from GFF coordinate mapping to the reference assembly. It is possible that this sequence differs from the transcript or amino acid sequence reported in NCBI RefSeq when the transcript or protein has its own NCBI RefSeq entry that differs from the genome assembly.

 Upper case bases for noncoding transcripts indicate mature transcript sequence (i.e., spliced exons when applicable) and for coding transcripts indicate mature transcript's coding region (i.e., CDS).

Expression

Primary Sources
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Iftap (Mmu)
iftap (Dre)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
Iftap molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Wdtc1Mus musculus
protein
  • affinity chromatography technology
PMID:27113764
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Genetic Interactions

No data available