Version: 8.0.0Date: Tue Jan 28 2025
Gene
Toe1
- Species
- Mus musculus
- Symbol
- Toe1
- Name
- target of EGR1, member 1 (nuclear)
- Synonyms
- 4930584N22Rik
- 4933424D16Rik
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable poly(A)-specific ribonuclease activity and snRNA binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in Cajal body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease).
- MGI Description
- PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality before E11.5. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR15092
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | TOE1 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Toe1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | toe1 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Danio rerio | toe1 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Caenorhabditis elegans | parn-2 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
Phenotype Term | Annotation details | References |
|---|---|---|
| No records match query. Try removing filters. | ||
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Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||
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Sequence Feature Viewer
- Genome location
- Chr4:116661199...116664785 - (3.59 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
2 interactor genes based on 2 annotations
Toe1 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | Atg16l1 | Mus musculus | protein |
| PMID:30196744 | |
protein | Wdtc1 | Mus musculus | protein |
| PMID:27113764 |
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