Gene

Steap3

Species
Mus musculus
Symbol
Steap3
Name
STEAP family member 3
Synonyms
  • 1010001D01Rik
  • pHyde
Biotype
protein coding gene
Automated Description
Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome membrane and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene results in microcytic anemia, increased erythrocyte cell number, abnormal reticulocyte morphology, anisopoikilocytosis, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, and thrombocytosis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14239
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
120.155M120.160M120.165M120.170M120.175M120.180M120.185M120.190M120.195M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions