Species

Mus musculus

Symbol

Washc1

Name

WASH complex subunit 1

Synonyms

1110049F14Rik
open reading frame 19

Biotype

protein coding gene

Automated Description

Enables gamma-tubulin binding activity and phosphatidylinositol 3-kinase inhibitor activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; meiotic nuclear division; and oocyte maturation. Acts upstream of or within several processes, including low-density lipoprotein particle clearance; positive regulation of cholesterol import; and positive regulation of protein localization to cell surface. Located in autophagosome; centrosome; and endosome. Part of BLOC-1 complex and WASH complex. Is expressed in several structures, including brain; genitourinary system; immune system; liver; and lung. Orthologous to several human genes including WASHC1 (WASH complex subunit 1).

MGI Description

PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality prior to E7.5 with increased cell death and autophagy. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR23331

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	WASHC1	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Homo sapiens	WASH4P	8 of 10	No	Yes	☐☐☑☑☑☑☑☑☑☑
Homo sapiens	WASH6P	8 of 10	No	Yes	☐☐☑☑☑☑☑☑☑☑
Homo sapiens	WASH2P	8 of 10	No	Yes	☐☐☑☑☑☑☑☑☑☑
Homo sapiens	WASH3P	8 of 10	No	Yes	☐☐☑☑☑☑☑☑☑☑
Rattus norvegicus	Washc1	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Xenopus tropicalis	washc1	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Danio rerio	wash1	10 of 10	Yes	Yes	☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogaster	wash	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Caenorhabditis elegans	ddl-2	7 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☐☐

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

Phenotype Term

Annotation details

References

abnormal amniotic cavity morphology

View

PMID:23974797

abnormal autophagy

View

Name	Type	Experimental condition	Modifier	References
Washc1^tm1.1Xya/Washc1^tm1.1Xya [background:] involves: 129 * FVB/N	genotype			PMID:23974797
Washc1^tm1Xya/Washc1^tm1Xya [background:] involves: 129	genotype			PMID:23974797

PMID:23974797

abnormal ectoplacental cavity morphology

View

PMID:23974797

abnormal embryo development

View

PMID:23974797

abnormal extraembryonic coelom morphology

View

PMID:23974797

embryonic lethality, complete penetrance

View

Name	Type	Experimental condition	Modifier	References
Washc1^tm1.2Ddb/Washc1^tm1.2Ddb [background:] involves: 129S4/SvJae * 129S4/SvJaeSor	genotype			PMID:22718907
Washc1^tm1.1Xya/Washc1^tm1.1Xya [background:] involves: 129 * FVB/N	genotype			PMID:23974797

increased cell death

View

PMID:23974797

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Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

Chr17:66418540...66427498 + (8.96 kb)

Assembly version

GRCm39

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category	Variant
Washc1^tm1.1Ddb	WASH^flox	allele
Washc1^tm1.1Xya		allele		Yes
Washc1^tm1Xya	WASH^flox	allele		Yes
Washc1^tm1.2Ddb		allele		Yes
NC_000083.7:g.66418690G>C		variant	rs51285644 SNP intron variant
NC_000083.7:g.66421949C>T		variant	rs240939394 SNP intron variant
NC_000083.7:g.66423824A>G		variant	rs585400497 SNP intron variant
NC_000083.7:g.66422123A>G		variant	rs227135207 SNP intron variant
NC_000083.7:g.66423833A>G		variant	rs583671409 SNP intron variant
NC_000083.7:g.66426858A>G		variant	rs50364320 SNP 3 prime UTR variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name	Associated Phenotypes	Source
Washc1^tm1.1Xya/Washc1^tm1.1Xya [background:] involves: 129 * FVB/N	abnormal amniotic cavity morphology abnormal autophagy	MGI
Washc1^tm1.2Ddb/Washc1^tm1.2Ddb [background:] involves: 129S4/SvJae * 129S4/SvJaeSor	embryonic lethality, complete penetrance	MGI
Washc1^tm1Xya/Washc1^tm1Xya [background:] involves: 129	abnormal autophagy	MGI

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Sequence Feature Viewer

Genome location

Chr17:66418540...66427498 + (8.96 kb)

Assembly version

GRCm39

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

MGI

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

33 interactor genes based on 33 annotations

Washc1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	BRK1	Homo sapiens	protein	affinity chromatography technology	biogrid:1468820	PMID:26496610
protein	CAPZA1	Homo sapiens	protein	affinity chromatography technology	biogrid:1458891	PMID:26496610
protein	CAPZA2	Homo sapiens	protein	affinity chromatography technology	biogrid:1458912	PMID:26496610
protein	CAPZB	Homo sapiens	protein	affinity chromatography technology	biogrid:1458934	PMID:26496610
protein	CCDC102A	Homo sapiens	protein	affinity chromatography technology	biogrid:1470972	PMID:26496610
protein	COL4A5	Homo sapiens	protein	affinity chromatography technology	biogrid:1459261	PMID:26496610
protein	COX7A2	Homo sapiens	protein	affinity chromatography technology	biogrid:1459295	PMID:26496610
protein	Cttn	Rattus norvegicus	protein	confocal microscopy	intact:EBI-9075607 imex:IM-17363-9 IntAct via IMEx	PMID:24344185
protein	Eea1	Mus musculus	protein	imaging technique	biogrid:2596597	PMID:29893854
protein	ENTR1	Homo sapiens	protein	affinity chromatography technology	biogrid:1465526	PMID:26496610

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Genetic Interactions

No data available