Predicted to enable oxysterol binding activity and protein sequestering activity. Acts upstream of or within several processes, including ear morphogenesis; negative regulation of fat cell differentiation; and negative regulation of lipid biosynthetic process. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; eye; ganglia; telencephalon ventricular layer; and vibrissa. Orthologous to human INSIG1 (insulin induced gene 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased body body weight, increased gonadal and subcutaneous fat pad, decreased circulating triglyceride level and abnormal adipocity differentiation. [provided by MGI curators]