Gene

Insig1

Species
Mus musculus
Symbol
Insig1
Name
insulin induced gene 1
Synonyms
  • 1810013C12Rik
  • AABR07060293.1
Biotype
protein coding gene
Automated Description
Predicted to enable oxysterol binding activity and protein sequestering activity. Acts upstream of or within several processes, including ear morphogenesis; negative regulation of fat cell differentiation; and negative regulation of lipid biosynthetic process. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; eye; ganglia; telencephalon ventricular layer; and vibrissa. Orthologous to human INSIG1 (insulin induced gene 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased body body weight, increased gonadal and subcutaneous fat pad, decreased circulating triglyceride level and abnormal adipocity differentiation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15301
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
28.277M28.278M28.279M28.280M28.281M28.282M28.283M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions