Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in several processes, including male meiosis I; seminiferous tubule development; and spermatogenesis. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas. [provided by MGI curators]