Gene

Ing2

Species
Mus musculus
Symbol
Ing2
Name
inhibitor of growth family, member 2
Synonyms
  • 2810011M06Rik
  • Ing1l
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Involved in several processes, including male meiosis I; seminiferous tubule development; and spermatogenesis. Acts upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and immune system. Orthologous to human ING2 (inhibitor of growth family member 2).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10333
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
48.121M48.122M48.123M48.124M48.125M48.126M48.127M48.128M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions