Enables histone H2AK119 ubiquitin ligase activity. Involved in random inactivation of X chromosome. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3).
MGI Description
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit limb defects and spleen agenesis. [provided by MGI curators]