Species

Mus musculus

Symbol

Wnk4

Name

WNK lysine deficient protein kinase 4

Synonyms

2010002J11Rik
Ac2-059

Biotype

protein coding gene

Automated Description

Enables chloride ion binding activity; ion channel inhibitor activity; and protein serine/threonine kinase activity. Involved in several processes, including ERK1 and ERK2 cascade; metal ion transport; and regulation of protein kinase activity. Acts upstream of or within chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Located in bicellular tight junction and cytoplasm. Part of protein-containing complex. Is active in cell body. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Used to study Gitelman syndrome and pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).

MGI Description

PHENOTYPE: Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR13902

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr11:101151393...101168235 + (16.84 kb)

Assembly version

GRCm39

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Wnk4 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

Wnk4 role	Wnk4 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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