Version: 8.0.0
Date: Tue Jan 28 2025
Lrch4
Mus musculusMGI:1917193
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Lrch4

Species
Mus musculus
Symbol
Lrch4
Name
leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms
  • 2810008P14Rik
  • 2900069C24Rik
Biotype
protein coding gene
Automated Description
Involved in membrane raft assembly and positive regulation of toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human LRCH4 (leucine rich repeats and calponin homology domain containing 4).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16083
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensLRCH410 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusLrch49 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriolrch410 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterLrch6 of 9YesNo☐ ☑☑☐☑☑☐☑☑  
Caenorhabditis eleganslrch-18 of 9YesYes☑ ☑☑☑☑☑☐☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Lrch3180356427 of 9☑☐☑☐☑☑☑☑☑ 
Lrch1276354407 of 9☑☐☑☐☑☑☑☑☑ 
Lrch2378351387 of 9☑☐☑☐☑☑☑☑☑ 
Mfhas1476435242 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc7577234242 of 9☑☐☐☐☐☐☐☑☐ 
Scrib667236252 of 9☑☐☐☐☐☐☐☑☐ 
Phlpp2773533222 of 9☑☐☐☐☐☐☐☑☐ 
Pidd1866535252 of 9☑☐☐☐☐☐☐☑☐ 
Phlpp1975130192 of 9☑☐☐☐☐☐☐☑☐ 
Erbin1063735222 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc271165532212 of 9☑☐☐☐☐☐☑☐☐ 
Lrrk11252134242 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc401350736222 of 9☑☐☐☐☐☐☐☑☐ 
Lrsam11443442262 of 9☐☐☐☐☐☐☑☑☐ 
Lrrc581538040262 of 9☑☐☐☐☐☐☐☑☐ 
Lrriq41634842282 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc391737440232 of 9☑☐☐☐☐☐☐☑☐ 
Lrrd11829145302 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc11927547312 of 9☑☐☐☐☐☐☐☑☐ 
Shoc22029143312 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc592136135222 of 9☐☐☐☐☐☐☑☑☐ 
Lrrc572227745282 of 9☐☐☐☐☐☐☑☑☐ 
Lrrc182324148282 of 9☑☐☐☐☐☐☑☐☐ 
Lrrc102421743323 of 9☑☐☐☐☐☐☑☑☐ 
Lrrc8a2521751282 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc8d2621551282 of 9☑☐☐☐☐☐☐☑☐ 
Lrrc692720148312 of 9☑☐☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000071.7:g.137627697C>Avariant
    SNP
    • intron variant
    NC_000071.7:g.137629758G>Avariant
    SNP
    • intron variant
    NC_000071.7:g.137630405T>Cvariant
    SNP
    • intron variant
    NC_000071.7:g.137630480T>Cvariant
    SNP
    • intron variant
    NC_000071.7:g.137632584A>Gvariant
    SNP
    • intron variant
    NC_000071.7:g.137634491C>Tvariant
    SNP
    • intron variant
    NC_000071.7:g.137632743C>Avariant
    SNP
    • intron variant
    NC_000071.7:g.137638902C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_000071.7:g.137639001A>Gvariant
    SNP
    • 3 prime UTR variant
    NC_000071.7:g.137637235G>Avariant
    SNP
    • intron variant
    Showing 1 - 10 of 234 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    3 interactor genes based on 4 annotations
    Lrch4 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Lmo2Mus musculus
    protein
    • two hybrid
    		PMID:26764384
    protein
    		Lmo2Mus musculus
    protein
    • affinity chromatography technology
    		PMID:26764384
    protein
    		Sting1Mus musculus
    protein
    • proximity labelling technology
    		PMID:32554809
    protein
    		Wdfy4Mus musculus
    protein
    • affinity chromatography technology
    		PMID:30409884
    Showing 1 - 4 of 4 rows
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    Genetic Interactions

    No data available