Gene

Ace2

Species
Mus musculus
Symbol
Ace2
Name
angiotensin converting enzyme 2
Synonyms
  • 2010305L05Rik
  • RIKEN cDNA 2010305L05 gene
Biotype
protein coding gene
Automated Description
Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
MGI Description
PHENOTYPE: Targeted disruption of this locus results in reduced cardiac contractility. Male mice hemizygous for a knock-out allele exhibit increased susceptibility to induced colitis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10514
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
162.925M162.930M162.935M162.940M162.945M162.950M162.955M162.960M162.965M162.970M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions