Gene

Ndufab1

Species
Mus musculus
Symbol
Ndufab1
Name
NADH:ubiquinone oxidoreductase subunit AB1
Synonyms
  • 2210401F17Rik
  • 2310039H15Rik
Biotype
protein coding gene
Automated Description
Predicted to enable acyl binding activity; acyl carrier activity; and mitochondrial large ribosomal subunit binding activity. Predicted to be involved in [2Fe-2S] cluster assembly; mitochondrial respiratory chain complex I assembly; and protein lipoylation. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1).
MGI Description
PHENOTYPE: Skeletal muscle-specific knock-out leads to smaller body size, hypoglycemia, hypoinsulinemia, reduced muscle and liver glycogen levels, disrupted mitochondrial cristae and premature death within five days after birth. Overexpression increases glucose metabolism and protects against diet-induced obesity. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR20863
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
121.688M121.690M121.692M121.694M121.696M121.698M121.700M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions