Predicted to enable several functions, including histone binding activity; transcription corepressor activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of filopodium assembly; regulation of postsynapse organization; and regulation of transcription by RNA polymerase II. Predicted to be located in chromosome; dendrite; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; early conceptus; female reproductive system; and urinary system. Orthologous to human ZMYND8 (zinc finger MYND-type containing 8).
MGI Description
PHENOTYPE: Mice homozygous for a conditional allele activated in mammary tissue exhibit reduced mammary tumors and abolished lung metastasis in a transgenic breast cancer model. [provided by MGI curators]