Gene

Borcs6

Species
Mus musculus
Symbol
Borcs6
Name
BLOC-1 related complex subunit 6
Synonyms
  • 2310047M10Rik
  • RIKEN cDNA 2310047M10 gene
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity. Predicted to be involved in lysosome localization. Predicted to be located in cytoplasmic side of lysosomal membrane. Predicted to be part of BORC complex. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and hemolymphoid system. Orthologous to human BORCS6 (BLOC-1 related complex subunit 6).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, small epiblast, egg cylinder degeneration, abnormal primitive streak formation, failure to gastrulate, and complete lethality prior to organogenesis with defects in visceral endoderm and embryo patterning and dysfunction of the endo-lysosomal pathway. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13440
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            68.9508M68.9510M68.9512M68.9514M68.9516M68.9518M68.9520M68.9522M68.9524M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Borcs6 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              Borcs6 role
              Borcs6 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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