Gene

Myh14

Species
Mus musculus
Symbol
Myh14
Name
myosin, heavy polypeptide 14
Synonyms
  • 2400004E04Rik
  • NMHC II-C
Biotype
protein coding gene
Automated Description
Enables several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele are healthy and survive to adulthood with no apparent defects. About 30% of knock-in mice either heterozygous or homozygous for a single amino acid mutation exhibit increased lymphoma incidence. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45615
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
44.26M44.27M44.28M44.29M44.30M44.31M44.32M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions