Predicted to enable several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Involved in embryo implantation and regulation of epithelial to mesenchymal transition. Acts upstream of or within double-strand break repair and regulation of isotype switching. Is active in cytosol and nucleus. Is expressed in allantois; blastocyst; and early embryo. Orthologous to human APLF (aprataxin and PNKP like factor).
MGI Description
PHENOTYPE: Mice homozygous for a gene trap allele exhibit decreased repair of gamma irradiation-induced DNA damage and increased microhomology at class switch recombination junctions in B cells. [provided by MGI curators]