Version: 8.0.0Date: Tue Jan 28 2025
Gene
Nme8
- Species
- Mus musculus
- Symbol
- Nme8
- Name
- NME/NM23 family member 8
- Synonyms
- 1700056P15Rik
- RIKEN cDNA 1700056P15 gene
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in axoneme; sperm cytoplasmic droplet; and sperm principal piece. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8).
- MGI Description
- PHENOTYPE: Homozygous mutant displays normal reproductive system phenotype [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46135
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | NME8 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Nme8 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Xenopus tropicalis | nme9 | 3 of 9 | Yes | Yes | ☐ ☐☐☑☑☐☑☐☐ |
| Danio rerio | nme9 | 3 of 10 | Yes | No | ☐ ☑☐☑☐☐☑☐☐ ☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| Nme9 | 1 | 428 | 33 | 23 | 3 of 9 | ☐☐☐☐☐☐☑☑☑ |
| Nme7 | 2 | 326 | 48 | 26 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
| Nme5 | 3 | 132 | 61 | 39 | 3 of 9 | ☑☐☐☐☐☑☐☑☐ |
| Nme4 | 4 | 224 | 36 | 23 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
| Nme6 | 5 | 136 | 51 | 30 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
| Nme3 | 6 | 147 | 48 | 24 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
| Nme1 | 7 | 139 | 48 | 25 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
| Nme2 | 8 | 129 | 50 | 26 | 2 of 9 | ☑☐☐☐☐☐☐☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
| all annotations | all disease by infectious agent | bacterial infectious disease | fungal infectious disease | parasitic infectious disease | viral infectious disease | all disease of anatomical entity | cardiovascular system disease | central nervous system disease | endocrine system disease | gastrointestinal system disease | hematopoietic system disease | immune system disease | integumentary system disease | musculoskeletal system disease | peripheral nervous system disease | reproductive system disease | respiratory system disease | sensory system disease | thoracic disease | urinary system disease | all disease of cellular proliferation | benign neoplasm | cancer | pre-malignant neoplasm | all genetic disease | chromosomal disease | monogenic disease | polygenic disease | all other disease | disease of mental health | disease of metabolism | physical disorder | syndrome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nme8 (Mmu) |
Cell color indicative of annotation volume
No data available
Alleles and Variants
No mapped variant information availableAllele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| Nme8tm1a(KOMP)Wtsi | allele | ||||||
| Nme8em1(IMPC)Bay | allele | ||||||
| Nme8em1Cya |
| allele | |||||
| Nme8em2Cya |
| allele | |||||
| Nme8tm1.1Arte |
| allele | |||||
| NC_000079.7:g.19833977A>G | variant | SNP
| |||||
| NC_000079.7:g.19840778G>A | variant | SNP
| |||||
| NC_000079.7:g.19862783G>A | variant | SNP
| |||||
| NC_000079.7:g.19863455G>A | variant | SNP
| |||||
| NC_000079.7:g.19863778A>G | variant | SNP
| |||||
Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| Nme8tm1.1Arte/Nme8tm1.1Arte Txndc2tm1.1Arte/Txndc2tm1.1Arte [background:] involves: C57BL/6 * C57BL/6NTac |
| MGI | |||
| Nme8tm1.1Arte/Nme8tm1.1Arte [background:] involves: C57BL/6NTac | MGI |
Showing 1 - 2 of 2 rows
per page
Sequence Feature Viewer
- Genome location
- Chr13:19829248...19881964 - (52.72 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
| all annotations | all anatomical structures | alimentary part of gastrointestinal system | chemosensory system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | mechanosensory system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | sensory system | vestibulo-auditory system | visual system | endoderm | ectoderm | mesoderm | mesenchyme | adipose tissue | appendage | entire extraembryonic component | imaginal precursor | pharyngeal arch | other | all stages | embryo stage | post embryonic, pre-adult | post-juvenile adult stage | all cellular components | extracellular region | plasma membrane | synapse | cell junction | cell projection | cytoplasmic vesicle | endosome | vacuole | golgi apparatus | endoplasmic reticulum | cytosol | mitochondrion | nucleus | chromosome | cytoskeleton | protein-containing complex | other locations | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nme8 (Mmu) |
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.