Gene

Ift57

Species
Mus musculus
Symbol
Ift57
Name
intraflagellar transport 57
Synonyms
  • 4833420A15Rik
  • Esrrbl1
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including cilium assembly; epithelial tube morphogenesis; and negative regulation of keratinocyte proliferation. Located in several cellular components, including cytoskeleton; dendrite terminus; and photoreceptor connecting cilium. Part of intraciliary transport particle B. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; limb bud; and node. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XVIII. Orthologous to human IFT57 (intraflagellar transport 57).
MGI Description
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis, abnormal left-right axis patterning, absence of embryonic cilia. random and delayed embryo turning, and abnormal neural tube development and morphology. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16011
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
49.52M49.53M49.54M49.55M49.56M49.57M49.58M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions