Enables DNA binding activity and chromatin binding activity. Predicted to be involved in transcription elongation-coupled chromatin remodeling and transcription initiation-coupled chromatin remodeling. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nucleosome. Is expressed in several structures, including central nervous system; early conceptus; gonad; and retina. Used to study atrioventricular septal defect. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog).
MGI Description
PHENOTYPE: Homozygosity for a mutation of highly conserved proline 495 leads to the death of half of newborns within the first day. [provided by MGI curators]