Involved in spermatogenesis. Located in acrosomal vesicle and sperm flagellum. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 7. Orthologous to human CT55 (cancer/testis antigen 55).
MGI Description
PHENOTYPE: Mice homozygous for a null allele show reduced susceptibility to weight loss, rectal prolapse and visible tumors in an AOM/DSS model of colitis and tumorogenesis. Mice homozygous for a different null allele show a progressive decline in male fertility along with defects in acrosome development, sperm individualization, excess cytoplasm removal and cumulus-oocyte complex penetration capacity, and an impaired autophagic process during spermatogenesis. [provided by MGI curators]