Predicted to enable protein serine/threonine kinase activity. Involved in cellular response to glucose starvation. Located in axoneme. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit early embryonic lethality before E7.5. Mice homozygous for a conditional allele activated in muscles exhibit symptoms of autophagic vacuolar myopathies.
[provided by MGI curators]