Gene

Sesn3

Species
Mus musculus
Symbol
Sesn3
Name
sestrin 3
Synonyms
  • 5630400E15Rik
  • BC003348
Biotype
protein coding gene
Automated Description
Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; regulation of signal transduction; and response to insulin. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex. Is expressed in brain; cortical plate; and embryo. Orthologous to human SESN3 (sestrin 3).
MGI Description
PHENOTYPE: When fed a high fat diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptake, increased hepatic steatosis, and decreased mitochondria in the liver. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12474
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
14.190M14.195M14.200M14.205M14.210M14.215M14.220M14.225M14.230M14.235M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions