Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; regulation of signal transduction; and response to insulin. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex. Is expressed in brain; cortical plate; and embryo. Orthologous to human SESN3 (sestrin 3).
MGI Description
PHENOTYPE: When fed a high fat diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptake, increased hepatic steatosis, and decreased mitochondria in the liver.
[provided by MGI curators]