Version: 8.0.0
Date: Tue Jan 28 2025
Rnf139
Mus musculusMGI:1923091
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Rnf139

Species
Mus musculus
Symbol
Rnf139
Name
ring finger protein 139
Synonyms
  • 4930555P18Rik
  • RIKEN cDNA 4930555P18 gene
Biotype
protein coding gene
Automated Description
Predicted to enable protease binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein destabilization; and regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex. Predicted to be active in endomembrane system. Is expressed in bladder; central nervous system; testis; and ureter. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased diet-induced liver apoptosis, inflammation and fibrosis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22763
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Rnf139 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Rnf139 role
            Rnf139 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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