Gene

Steap4

Species
Mus musculus
Symbol
Steap4
Name
STEAP family member 4
Synonyms
  • 1110021O17Rik
  • AI481214
Biotype
protein coding gene
Automated Description
Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Involved in fat cell differentiation. Acts upstream of or within copper ion import; iron import into cell; and iron ion import across cell outer membrane. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14239
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
8.012M8.014M8.016M8.018M8.020M8.022M8.024M8.026M8.028M8.030M8.032M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions