Enables cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Involved in fat cell differentiation. Acts upstream of or within copper ion import; iron import into cell; and iron ion import across cell outer membrane. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia. [provided by MGI curators]