Predicted to enable microtubule binding activity. Involved in homologous chromosome orientation in meiotic metaphase I and positive regulation of meiosis I spindle assembly checkpoint. Located in cytoplasm and kinetochore. Is expressed in cerebral cortex ventricular layer; telencephalon; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1).
MGI Description
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6. Mice homozygous for a conditional allele activated in NPCs exhibit postnatal and premature death and microcephaly associated with NPC apoptosis and premature differentiation.
[provided by MGI curators]