Gene

Cmya5

Species
Mus musculus
Symbol
Cmya5
Name
cardiomyopathy associated 5
Synonyms
  • 2310076E16Rik
  • 2310076E21Rik
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and protein phosphatase inhibitor activity. Acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade and regulation of skeletal muscle adaptation. Located in costamere. Is expressed in heart; skeletal muscle; and somite. Orthologous to human CMYA5 (cardiomyopathy associated 5).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit impaired cardiac structure and function, more severe in female mice, and male mice exhibit schizophrenia-associated symptoms. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24099
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            93.18M93.19M93.20M93.21M93.22M93.23M93.24M93.25M93.26M93.27M93.28M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cmya5 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Cmya5 role
              Cmya5 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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