Gene

Kdm8

Species
Mus musculus
Symbol
Kdm8
Name
lysine (K)-specific demethylase 8
Synonyms
  • 3110005O21Rik
  • Jmjd5
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and p53 binding activity. Involved in circadian regulation of gene expression and protein destabilization. Acts upstream of or within several processes, including fibroblast proliferation; regulation of DNA-binding transcription factor activity; and regulation of signal transduction by p53 class mediator. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and trachea. Orthologous to human KDM8 (lysine demethylase 8).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene leads to complete embryonic lethality during organogenesis associated with severe growth retardation and abnormal embryo turning. Observed phenotypes include open neural tubes and absent vitelline blood vessels. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12461
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kdm8 molecule type
          Interactor gene
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            Genetic Interactions

            Kdm8 role
            Kdm8 genetic perturbation
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