Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human HEG1 (heart development protein with EGF like domains 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired integrity of the heart, blood vessels and lymphatic vessels, resulting in hemopericardium, lung hemorrhage, lymphangiectasis, and chylous ascites, as well as embryonic and postnatal lethality.
[provided by MGI curators]