Version: 8.0.0
Date: Tue Jan 28 2025
Zfyve26
Mus musculusMGI:1924767
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Zfyve26

Species
Mus musculus
Symbol
Zfyve26
Name
zinc finger, FYVE domain containing 26
Synonyms
  • 9330197E15Rik
  • A630028O16Rik
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein kinase binding activity. Acts upstream of or within lysosome organization. Predicted to be located in early endosome; late endosome; and lysosome. Predicted to be active in centrosome and midbody. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26).
MGI Description
PHENOTYPE: Mice homozygous for a null allele display a late-onset spastic gait disorder with cerebellar ataxia, axon degeneration, and progressive loss of cortical motoneurons and Purkinje cells preceded by accumulation of autofluorescent, electron-dense, membrane-enclosed material in lysosomal structures. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46591
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            79.28M79.29M79.30M79.31M79.32M79.33M79.34M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Zfyve26 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Zfyve26 role
              Zfyve26 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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