Version: 8.0.0
Date: Tue Jan 28 2025
Hook1
Mus musculusMGI:1925213
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hook1

Species
Mus musculus
Symbol
Hook1
Name
hook microtubule tethering protein 1
Synonyms
  • A930033L17Rik
  • abnormal spermatazoon head shape
Biotype
protein coding gene
Automated Description
Enables actin binding activity and microtubule binding activity. Acts upstream of or within Golgi organization; cytoplasmic microtubule organization; and manchette assembly. Located in microtubule cytoskeleton. Is expressed in embryo; forelimb bud; spermatid; and testis. Orthologous to human HOOK1 (hook microtubule tethering protein 1).
MGI Description
PHENOTYPE: Homozygous mice have abnormal ladle shaped sperm with up to 40% lacking a flagella. Nonetheless, most males breed, although litter size is reduced. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18947
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Hook3171974567 of 9☑☐☑☐☑☑☑☑☑ 
Hook2276761427 of 9☑☐☑☐☑☑☑☑☑ 
Ccdc88c380945243 of 9☑☐☐☐☐☐☑☑☐ 
Ccdc88a480143233 of 9☑☐☐☐☐☐☑☑☐ 
Ccdc88b573939233 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            95.86M95.87M95.88M95.89M95.90M95.91M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Must provide at least one subject
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Hook1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Hook1 role
              Hook1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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