Version: 8.0.0
Date: Tue Jan 28 2025
Adgra2
Mus musculusMGI:1925810
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Adgra2

Species
Mus musculus
Symbol
Adgra2
Name
adhesion G protein-coupled receptor A2
Synonyms
  • 8430414O08Rik
  • 9530074E10Rik
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; regulation of establishment of blood-brain barrier; and sprouting angiogenesis. Acts upstream of or within angiogenesis; negative regulation of vascular endothelial growth factor signaling pathway; and positive regulation of endothelial cell migration. Located in cell surface and plasma membrane. Is expressed in several structures, including cardiovascular system; cerebral cortex; embryo mesenchyme; limb bud; and nose. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2).
MGI Description
PHENOTYPE: Mice homozygous for null mutations display fetal or perinatal lethality with CNS hemorrhage and angiogenic arrest in the CNS. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45930
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            27.580M27.585M27.590M27.595M27.600M27.605M27.610M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Adgra2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Adgra2 role
              Adgra2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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