Acts upstream of or within several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22).
MGI Description
PHENOTYPE: Mice homozygous for one null allele display infertility, decreased grip strength and decreased prepulse inhibition. Mice homozygous for a second null allele display partial lethality and decreased cell proliferation. [provided by MGI curators]