Gene

Ppp1r15a

Species
Mus musculus
Symbol
Ppp1r15a
Name
protein phosphatase 1, regulatory subunit 15A
Synonyms
  • Gadd34
  • growth arrest and DNA-damage-inducible 34
Biotype
protein coding gene
Automated Description
Enables protein phosphatase binding activity and protein phosphatase regulator activity. Involved in regulation of macromolecule metabolic process and response to endoplasmic reticulum stress. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and hemolymphoid system gland. Used to study thalassemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A).
MGI Description
PHENOTYPE: Homozygous mutant mice show abnormal cellular responses to either ER- or oxidative- stress. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16489
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
45.1725M45.1730M45.1735M45.1740M45.1745M45.1750M45.1755M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions