Gene

Slc29a1

Species
Mus musculus
Symbol
Slc29a1
Name
solute carrier family 29 (nucleoside transporters), member 1
Synonyms
  • 1200014D21Rik
  • AA407560
Biotype
protein coding gene
Automated Description
Enables neurotransmitter transmembrane transporter activity; purine nucleoside transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in neurotransmitter uptake and nucleoside transport. Acts upstream of or within nucleoside transport. Is active in plasma membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; hindlimb phalanx; liver; and skeletal musculature. Used to study alcohol dependence and diffuse idiopathic skeletal hyperostosis. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)).
MGI Description
PHENOTYPE: Mice homozygous for a targeted null allele exhibit a slightly decreased body weight, increased alcohol preference and alcohol consumption, and reduced hypnotic and ataxic responses to ethanol associated with a reduction in adenosine tone. Adenosine uptake is almost completely abolished in mice homozygous for a knock-out allele. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10332
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            45.898M45.900M45.902M45.904M45.906M45.908M45.910M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Slc29a1 molecule type
            Interactor gene
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              Genetic Interactions

              Slc29a1 role
              Slc29a1 genetic perturbation
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