Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of cell cycle; negative regulation of nucleobase-containing compound metabolic process; and protein-containing complex assembly. Acts upstream of or within animal organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and primitive streak. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication. [provided by MGI curators]