Gene

Gmnn

Species
Mus musculus
Symbol
Gmnn
Name
geminin
Synonyms
  • AW546347
  • expressed sequence AW546347
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of cell cycle; negative regulation of nucleobase-containing compound metabolic process; and protein-containing complex assembly. Acts upstream of or within animal organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and primitive streak. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit early embryonic lethality, defective inner cell mass formation, and endoreduplication. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13372
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
24.936M24.937M24.938M24.939M24.940M24.941M24.942M24.943M24.944M24.945M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions